Pifithrin-μ

A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.

Cell permeable: yes

Primary Target
p53 interaction with Bcl-xL and Bcl-2 proteins

Product does not compete with ATP.

Reversible: no

Packaged under inert gas

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Leu, J., et al. 2009. Mol. Cell36, 15.
Strom, E., et al. 2006. Nat. Chem. Biol.2, 474.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany