506126
p38 MAP Kinase Inhibitor
The p38 MAP Kinase Inhibitor, also referenced under CAS 219138-24-6, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
p38 MAP Kinase Inhibitor, 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one
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所有图片(1)
About This Item
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质量水平
方案
≥95% (HPLC)
表单
solid
效能
35 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale yellow
溶解性
DMSO: 25 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C20H13ClFN3O/c21-15-3-7-17(8-4-15)25-20(26)18(13-1-5-16(22)6-2-13)19(24-25)14-9-11-23-12-10-14/h1-12,24H
InChI key
DZFBYHUKZSRPHU-UHFFFAOYSA-N
一般描述
A potent p38 MAP kinase inhibitor (IC50 = 35 nM).
生化/生理作用
Cell permeable: no
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
de Laszlo, S.E., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2689.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
S E de Laszlo et al.
Bioorganic & medicinal chemistry letters, 8(19), 2689-2694 (1999-01-05)
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl-2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrol e (L-167307) reduces secondary paw swelling in the rat adjuvant arthritis model: ID50 = 7.4 mg/kg/b.i.d.
Guoqi Zhang et al.
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