产品名称
蝇蕈醇,
SMILES string
[N+H3]Cc1[o]nc(c1)[O-]
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
InChI key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
water: 100 mM
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
主要靶标
GABAA
GABAA
Disclaimer
毒性：有毒（F）
General description
一种蘑菇毒蝇伞的成分和精神活性成分，作为GABAA 受体的有效激动剂（新生大鼠和成年大鼠的EC50分别为28 µM和33 µM），对高亲和力受体亚型具有优先功效和选择性。研究表明可渗透血脑屏障。损害联想和记忆功能。
Other Notes
Chandra, D., et al. 2010.Neuropsychopharmacology.35, 999.
Fischer, H., et al. 2005.J. Physiol.564, 465.
Ramirez, D.R., et al. 2005.Neurobiol.Learning and Memory.84, 184.
Fischer, H., et al. 2005.J. Physiol.564, 465.
Ramirez, D.R., et al. 2005.Neurobiol.Learning and Memory.84, 184.
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Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Donna R Ramirez et al.
Neurobiology of learning and memory, 84(3), 184-191 (2005-08-10)
A matching-to-position (MTP) paradigm was altered to influence the type of associations a rat would use to solve the task. Our main behavioral manipulation was the application of the differential outcomes procedure (DOP). The DOP involves correlating each to-be-remembered event
Dev Chandra et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(4), 999-1007 (2009-12-25)
Muscimol has been regarded as a universal agonist for all gamma-aminobutyric acid type A receptor (GABA(A)-R) subtypes. However, brain regional distribution of muscimol's high-affinity binding sites greatly differs from those of other binding sites of the GABA(A)-R. To test whether
Harald Fischer et al.
The Journal of physiology, 564(Pt 2), 465-474 (2005-02-26)
The effects of gamma-aminobutyric acid (GABA) on the electrophysiological properties of intracardiac neurones were investigated in the intracardiac ganglion plexus in situ and in dissociated neurones from neonatal, juvenile and adult rat hearts. Focal application of GABA evoked a depolarizing
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