检测方案
≥99% (HPLC)
质量水平
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 100 mM
储存温度
2-8°C
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
InChI key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
一般描述
一种蘑菇毒蝇伞的成分和精神活性成分，作为GABAA 受体的有效激动剂（新生大鼠和成年大鼠的EC50分别为28 µM和33 µM），对高亲和力受体亚型具有优先功效和选择性。研究表明可渗透血脑屏障。损害联想和记忆功能。
生化/生理作用
主要靶标
GABAA
GABAA
警告
毒性：有毒（F）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他说明
Chandra, D., et al. 2010.Neuropsychopharmacology.35, 999.
Fischer, H., et al. 2005.J. Physiol.564, 465.
Ramirez, D.R., et al. 2005.Neurobiol.Learning and Memory.84, 184.
Fischer, H., et al. 2005.J. Physiol.564, 465.
Ramirez, D.R., et al. 2005.Neurobiol.Learning and Memory.84, 184.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Dev Chandra et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(4), 999-1007 (2009-12-25)
Muscimol has been regarded as a universal agonist for all gamma-aminobutyric acid type A receptor (GABA(A)-R) subtypes. However, brain regional distribution of muscimol's high-affinity binding sites greatly differs from those of other binding sites of the GABA(A)-R. To test whether
Harald Fischer et al.
The Journal of physiology, 564(Pt 2), 465-474 (2005-02-26)
The effects of gamma-aminobutyric acid (GABA) on the electrophysiological properties of intracardiac neurones were investigated in the intracardiac ganglion plexus in situ and in dissociated neurones from neonatal, juvenile and adult rat hearts. Focal application of GABA evoked a depolarizing
Donna R Ramirez et al.
Neurobiology of learning and memory, 84(3), 184-191 (2005-08-10)
A matching-to-position (MTP) paradigm was altered to influence the type of associations a rat would use to solve the task. Our main behavioral manipulation was the application of the differential outcomes procedure (DOP). The DOP involves correlating each to-be-remembered event
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