5.05986
SR 95531
≥98% (HPLC), solid, GABAA receptor antagonist, Calbiochem®
别名:
SR95531 (Gabazine), GABA A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531
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所有图片(1)
About This Item
经验公式（希尔记法）:
C15H17N3O3 · xHBr
CAS号:
分子量:
287.31 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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产品名称
SR95531 (Gabazine),
方案
≥98% (HPLC)
质量水平
表单
solid
效能
440 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 25 mM
储存温度
2-8°C
SMILES字符串
[Br-].[N+H2]=C1N(N=C(C=C1)c2ccc(cc2)OC)CCCC(=O)O
InChI
1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H
InChI key
GFZHNFOGCMEYTA-UHFFFAOYSA-N
一般描述
A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (Kb = 190 µM).
A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 mM). Also shown to block glycine receptors, but with low affinity (Kb = 190 mM).
生化/生理作用
Primary Target
GABAA
GABAA
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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