推荐产品
方案
≥99% (HPLC)
质量水平
表单
solid
效能
0.4 nM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
water: soluble
储存温度
2-8°C
SMILES字符串
Clc1ccc(cc1)N2CCN(CC2)Cc3c4c([nH]c3)nccc4
InChI
1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
InChI key
OGJGQVFWEPNYSB-UHFFFAOYSA-N
一般描述
Selective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
生化/生理作用
Primary Target
D₄
D₄
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Li, H. et al., 2013. J. Neurosci.33, 3135.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.
Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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