5.05877
(S)-(-)-Raclopride
别名:
(S)-(-)-Raclopride, Dopamine Receptor D2 Antagonist, (S)-Raclopride, Raclopride
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关于此项目
经验公式（希尔记法）:
C15H20Cl2N2O3
化学文摘社编号:
分子量:
347.24
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
Clc1c(c(c(c(c1)Cl)O)C(=O)NC[C@@H]2N(CCC2)CC)OC
InChI
1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1
InChI key
WAOQONBSWFLFPE-SECBINFHSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 100 mM
ethanol: 25 mM
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
D2-like dopamine receptor antagonist targeting D2R (pKi =8.0), D3R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D2 like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D2 Receptor selectivity in various preps shows IC50 values around 32 nM.
Other Notes
Dang, Y. H. et al. 2010. Neurosci.169, 1872.
Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.
Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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