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方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 100 mM
ethanol: 25 mM
储存温度
2-8°C
SMILES字符串
Clc1c(c(c(c(c1)Cl)O)C(=O)NC[C@@H]2N(CCC2)CC)OC
InChI
1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1
InChI key
WAOQONBSWFLFPE-SECBINFHSA-N
一般描述
D2-like dopamine receptor antagonist targeting D2R (pKi =8.0), D3R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D2 like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D2 Receptor selectivity in various preps shows IC50 values around 32 nM.
生化/生理作用
Reversible: yes
警告
Toxicity: Standard Handling (A)
其他说明
Dang, Y. H. et al. 2010. Neurosci.169, 1872.
Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.
Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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