检测方案
≥98% (HPLC)
质量水平
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 100 mM
储存温度
−20°C
InChI
1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13;1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35);4-6H2,1-3H3/t16-,19-,20-,23-;/m1./s1
InChI key
HVOVBTNCGADRTH-WBLDMZOZSA-N
一般描述
A prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15 µM vs 50 µM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice.
警告
Toxicity: Standard Handling (A)
其他说明
Messemer, N., et al. 2013. Neuropharmacology. 73, 122.
Michel, A.D., et al. 2001. Br. J. Pharmacol.132, 1501.
Erb, L., et al. 1990. J. Biol. Chem.265, 7424.
William, N., and Coleman, P.S. 1982. J. Biol. Chem.257, 2834.
Michel, A.D., et al. 2001. Br. J. Pharmacol.132, 1501.
Erb, L., et al. 1990. J. Biol. Chem.265, 7424.
William, N., and Coleman, P.S. 1982. J. Biol. Chem.257, 2834.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
L Erb et al.
The Journal of biological chemistry, 265(13), 7424-7431 (1990-05-05)
ATP, 3'-O-(4-benzoyl)benzoyl-ATP (BzATP), a photoaffinity analog of ATP, and several other ATP analogs induced an increase in plasma membrane permeability to monovalent ions and normally impermeant metabolites, including nucleotides, in transformed 3T6 mouse fibroblasts. The rank order of agonist potency
Nanette Messemer et al.
Neuropharmacology, 73, 122-137 (2013-06-04)
Neurogenesis requires the balance between the proliferation of newly formed progenitor cells and subsequent death of surplus cells. RT-PCR and immunocytochemistry demonstrated the presence of P2X7 receptor mRNA and immunoreactivity in cultured neural progenitor cells (NPCs) prepared from the adult
A D Michel et al.
British journal of pharmacology, 132(7), 1501-1508 (2001-03-27)
1. 2'-& 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) is the prototypic agonist for P2X(7) receptors. In this study we demonstrate that bovine serum albumin (BSA) can affect the potency of BzATP at P2X receptors. 2. BzATP potency (pEC(50)) to stimulate ethidium accumulation in cells
Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate.
N Williams et al.
The Journal of biological chemistry, 257(6), 2834-2841 (1982-03-25)
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