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Merck
CN
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主要文件

5.05378

Sigma-Aldrich

IKK Inhibitor VII

InSolution, ≥97%, 10 mM in DMSO, potent, selective, and ATP-competitive inhibitor of IKK

别名:

InSolution IKK Inhibitor VII, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII, IKK 16, IKK 16, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII

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About This Item

经验公式（希尔记法）:
C28H29N5OS
CAS号:
873225-46-8
分子量:
483.63
MDL编号:
MFCD23704180
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥97% (HPLC)

表单

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

储存温度

−70°C

SMILES字符串

[s]1c2c(cc1c3nc(ncc3)Nc4ccc(cc4)C(=O)N5CCC(CC5)N6CCCC6)cccc2

InChI

1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31)

InChI key

BWZJBXAPRCVCKQ-UHFFFAOYSA-N

一般描述

A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.

生化/生理作用

Cell permeable: yes
Primary Target
IKK-2, IKK complex, and IKK-1
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 µg/103 µL) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

其他说明

Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett.16, 108.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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