推荐产品
方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 100 mg/mL
储存温度
10-30°C
SMILES字符串
N([C@H]([C@@H](O)COc1c2c(c(cc1)C)CCC2)C)C(C)C
InChI
1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3/t13-,16-/m0/s1
InChI key
VFIDUCMKNJIJTO-BBRMVZONSA-N
一般描述
ICI-118,551 reduces hemangioblastoma viability by promoting cell apoptosis and inhibits the formation of hemangiospheres from VHL tumor cells. This antiangiogenic agent inhibits HIF-target genes. It also blocks constitutively activated HIF signaling in hemangioblastomas associated with von Hippel-Lindau disease. ICI-118,551 is a potent inhibitor of isoprenaline-stimulated adenylate cyclase activity in rabbit ciliary process cell preparations.
生化/生理作用
Primary Target
→2 adrenergic receptors
→2 adrenergic receptors
Reversible: yes
Target Ki: 1.2, 120 and 257 nM for →2, →1 and →3 receptors respectively.
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Bilski, A., et al. 1983. J. Cardiovasc. Pharmacol.5, 430.
Cook, S. et al. 1993. Br. J .Pharmacol.109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol.275, 199.
Strosberg, A., et al. 1996. TiPS17, 373.
Cook, S. et al. 1993. Br. J .Pharmacol.109, 1140.
Ten Berge, R., et al. 1995. Eur. J. Pharmacol.275, 199.
Strosberg, A., et al. 1996. TiPS17, 373.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.
Nathanson JA
British Journal of Pharmacology, 83(3), 821-821 (1984)
The beta2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease
Cuesta AM, et al.
Scientific reports, 9(1), 10062-10062 (2019)
The beta2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease
Cuesta AM, et al.
Scientific Reports, 9(1), 10062-10062 (2019)
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