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方案
≥98% (NMR)
质量水平
表单
solid
效能
5.5 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
water: 100 mM
储存温度
2-8°C
SMILES字符串
[Br-].[Br-].[N+]6(CCCCC6)([C@@H]1[C@@H]([C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@@H]([C@H](C4)[N+]5(CCCCC5)C)OC(=O)C)CC3)C)CC2)C1)C)OC(=O)C)C
InChI
1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
InChI key
NPIJXCQZLFKBMV-YTGGZNJNSA-L
一般描述
A highly potent competitive antagonist selective for nAChRs (IC50 = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.
生化/生理作用
Primary Target
nAChR
nAChR
警告
Toxicity: Toxic (F)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Lowenick et al., 2001. Eur. J. Pharmacol.413, 31.
Melnikov, L., et al., 1999. Gen Pharmacol.33, 313.
Maestrone, E., et al., 1994. Br. J. Pharmacol.111, 283.
Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol.335, 367.
Melnikov, L., et al., 1999. Gen Pharmacol.33, 313.
Maestrone, E., et al., 1994. Br. J. Pharmacol.111, 283.
Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol.335, 367.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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