5.05026
DNQX Disodium Salt
别名:
DNQX Disodium Salt, AMPA Glutamate Receptor Antagonist, DNQX, Kainate Glutamate Receptor Antagonist, DNQX
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关于此项目
经验公式（希尔记法）:
C8H2N4Na2O6
化学文摘社编号:
分子量:
296.10
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
storage temp.
2-8°C
SMILES string
[N+](=O)([O-])c1cc2[nH][c]([c]([nH]c2cc1[N+](=O)[O-])=O)=O
InChI
1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChI key
RWVIMCIPOAXUDG-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
dark brown
solubility
H2O: 100 mM
Quality Level
General description
A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC50 = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.
Biochem/physiol Actions
Primary Target
AMPA
AMPA
Secondary Target
GluK2
GluK2
Target IC50: 0.19 to 1.66 uM
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
Honor, T., et al. 1998. Science.241, 701.
Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49.
Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.
Honor, T., et al. 1998. Science.241, 701.
Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49.
Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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