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Merck
CN
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主要文件

安全信息

5.04904

Sigma-Aldrich

Ifenprodil Hemitartrate

别名:

Ifenprodil Hemitartrate, erythro-4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemitartrate

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About This Item

经验公式（希尔记法）:
C21H27NO2 · 0.5C4H6O6
CAS号:
23210-58-4
分子量:
400.49
MDL编号:
MFCD01529999
UNSPSC代码:
12352200

方案

≥99% (HPLC)

质量水平

100

表单

solid

效能

0.15 μM IC50

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 100 mM

储存温度

2-8°C

InChI

1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

InChI key

DMPRDSPPYMZQBT-CEAXSRTFSA-N

一般描述

A partial non-competitive antagonist highly selective for GluN1/N2B subtype NMDA receptors (IC50 = 0.15 µM, maximal inhibition ˜90%) over other subtypes (IC50 = 39, 29, 76 µM for GluN1/N2A, GluN1/N2C and GluN1/N2D subtype receptors, respectively). Frequently used in studies of various brain functions and disorders involving neural transmissions mediated by GluN1/N2B subtype NMDA receptors.
A partial non-competitive antagonist highly selective for GluN1/N2B subtype NMDA receptors (IC50 = 0.15 µM, maximal inhibition ˜90%) over other subtypes (IC50 = 39, 29, 76 µM for GluN1/N2A, GluN1/N2C and GluN1/N2D subtype receptors, respectively). Frequently used in studies of various brain functions and disorders involving neural transmissions mediated by GluN1/N2B subtype NMDA receptors.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Primary Target
GluN1/N2B subtype NMDA receptors

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Zhang, H., et al. 2013. Mol. Brain.6, 13.
Kishimoto, A., et al. 2013. J. Clin. Psychopharmacol.33, 143.
Bhat, J., et al. 2013. Mol. Pharmacol.83, 9.
Amico-Ruvio, S., et al. 2012. 82, 1074, 81.
Bhattacharya, P., et al. 2012. Med. Hypotheses.79, 516.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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