InChI key
NEWKHUASLBMWRE-UHFFFAOYSA-N
InChI
1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
Quality Level
General description
A non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36 nM). Also a positive allosteric modulator of mGlu4and weak anatagonist of NMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson′s disease.
Biochem/physiol Actions
Primary Target
mGlu₅ receptors
mGlu₅ receptors
Preparation Note
Following reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Manago, F., et al. 2013. Psychopharmacol. (Berl)226, 541.
Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry.40, 18.
Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England)1, 355.
Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics.319, 254.
Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol.132, 1423.
Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry.40, 18.
Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England)1, 355.
Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics.319, 254.
Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol.132, 1423.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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