5.04042
Doxorubicin Hydrochloride
InSolution, ≥98%
别名:
InSolution Doxorubicin, Hydrochloride, Adriamycin, HCl, 14-Hydroxydaunomycin, HCl
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关于此项目
经验公式（希尔记法）:
C27H29NO11 · xHCl
化学文摘社编号:
分子量:
543.52 (free base basis)
UNSPSC Code:
12352101
MDL number:
产品名称
Doxorubicin Hydrochloride, InSolution, ≥98%
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-FGBJBKNOSA-N
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
protect from light
storage temp.
−70°C
Quality Level
Physical form
A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.
Disclaimer
Toxicity: Standard Handling (A)
General description
A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl in H₂O.
An anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.
Other Notes
A′Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol.13, 726.
Nooter, K., et al. 1995. Br. J. Cancer71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.
Nooter, K., et al. 1995. Br. J. Cancer71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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