所有图片(1)
About This Item
经验公式（希尔记法）:
C17H21N7O4
CAS号:
分子量:
387.39
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
产品名称
mTOR活化剂，MHY1485,
方案
≥97% (HPLC)
质量水平
表单
solid
效能
~2 μM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale yellow
溶解性
DMSO: 12.5 mg/mL
储存温度
2-8°C
SMILES字符串
C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O
InChI key
VHYUALWDIXAVIZ-UHFFFAOYSA-N
一般描述
MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.
应用
mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).
生化/生理作用
可逆性：是
细胞可渗透性：具有
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Choi, Y. J., et al. 2012.PLoS.One.7, e43418.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Tumor necrosis factor alpha-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson?s disease via the NFkappaB and mTOR pathways
Chi M, et al.
Neuroscience Letters, 805, 137223-137223 (2023)
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Choi YJ, et al.
Testing (2012)
Yeon Ja Choi et al.
PloS one, 7(8), e43418-e43418 (2012-08-29)
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During the autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in the cytoplasm and finally fuse
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
Choi YJ, et al.
PLoS ONE (2012)
MHY1485 activates mTOR and protects osteoblasts from dexamethasone
Zhao S, et al.
Biochemical and biophysical research communications, 481(3-4), 212-218 (2016)
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