质量水平
检测方案
≥97% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL
ethanol: 5 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3
InChI key
NEQZWEXWOFPKOT-UHFFFAOYSA-N
一般描述
一种天然分离的可渗透细胞的真菌间苯二酚内酯,以ATP竞争性和不可逆的方式作为针对MAPKKK TAK1活性(IC50 =8 nM)的选择性和高效抑制剂,同时仅在更高的浓度下抑制MEK1(IC50=411 nM)和其他三种MAPKKK(MEKK1,ASK1和MEKK4的IC50 ≥268 nM)。显示抑制293细胞中IL-1诱导的/TAK1介导的JNK和p38磷酸化,但不抑制H2O2诱导的/TAK1非依赖性JNK和p38磷酸化。(5Z)-玉米醇,弯孢属(目录号499609)可以用作阴性对照。
警告
毒性:标准处理(A)
重悬
复溶后,等分并冷冻保存(-20°C)。贮备液在-20°C下可稳定保存至多6个月。
其他说明
Windheim, M., et al. 2007.Biochem.J.404, 179.
Choo, M.K., et al. 2006.Mol.Cancer Ther.5, 2970.
Safwat, N., et al. 2005.Endocrinology146, 4814.
Ninomiya-Tsuji, J., et al. 2003.J. Biol. Chem.278, 18485.
Rawlins, P., et al. 1999.Int. J. Immunopharmacol.21, 799.
Choo, M.K., et al. 2006.Mol.Cancer Ther.5, 2970.
Safwat, N., et al. 2005.Endocrinology146, 4814.
Ninomiya-Tsuji, J., et al. 2003.J. Biol. Chem.278, 18485.
Rawlins, P., et al. 1999.Int. J. Immunopharmacol.21, 799.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Biomolecules, 10(9) (2020-08-23)
Twenty natural remedies traditionally used against different inflammatory diseases were probed for their potential to suppress the expression of the inflammatory markers E-selectin and VCAM-1 in a model system of IL-1 stimulated human umbilical vein endothelial cells (HUVEC). One third
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