product name
诺考达唑, Inhibitor of mitosis.
质量水平
检测方案
≥99% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
pale yellow
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
10-30°C
InChI
1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChI key
KYRVNWMVYQXFEU-UHFFFAOYSA-N
一般描述
有丝分裂抑制剂。对培养中的哺乳动物细胞具有高度特异性的抗微管活性。促进微管蛋白解聚。也可以50 mM的DMSO溶液（货号487929）提供。
有丝分裂抑制剂。对培养中的哺乳动物细胞具有高度特异性的抗微管活性。促进微管蛋白解聚。还充当癌症相关激酶ABL，c-KIT，BRAF和MEK（Kd<2 µM）的高亲和力配体。
生化/生理作用
主要靶标
促进微管蛋白解聚
促进微管蛋白解聚
产物不与ATP竞争。
可逆：否
细胞渗透性：否
警告
毒性：致癌/致畸（D）
重悬
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。贮备液在4°C下可稳定长达1周，在-20°C下可稳定长达1年。
其他说明
Park, H., et al. 2011.Chem. Med. Chem.in press.
Bunz, F., et al. 1998.Science 282, 1497.
Fleischman, L.F., et al. 1993.Oncogene8, 771.
Pomies, P., and Block, M.R.1992.Biochem.Biophys.Res. Commun.189, 1429.
Rennison, M.E., et al. 1992.J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992.J. Cell Sci.103, 1167.
Bunz, F., et al. 1998.Science 282, 1497.
Fleischman, L.F., et al. 1993.Oncogene8, 771.
Pomies, P., and Block, M.R.1992.Biochem.Biophys.Res. Commun.189, 1429.
Rennison, M.E., et al. 1992.J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992.J. Cell Sci.103, 1167.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Muta. 2 - Repr. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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