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Merck
CN
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文件

安全信息

481990

Sigma-Aldrich

尼日利亚菌素钠盐,吸水链霉菌

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

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别名:
尼日利亚菌素钠盐,吸水链霉菌, 抗生素K178
经验公式(希尔记法):
C40H67O11 · Na
CAS号:
分子量:
746.94
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥98% (TLC)

形式

lyophilized

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

溶解性

chloroform: soluble
ethanol: soluble
ethyl acetate: soluble

运输

ambient

储存温度

2-8°C

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1

InChI key

MOYOTUKECQMGHE-KKCUGXASSA-M

一般描述

一种可催化碱金属电子中性交换H+(反向运输)的单羧酸。按以下特异性排列进行单价阳离子跨膜运输:K+>Rb+>Cs+>>Na+。一种可通过促进离子跨膜扩散而杀死细菌的抗生素。破坏膜电位并刺激线粒体ATP酶活性。
破坏膜电位并刺激线粒体中的ATP酶活性。按以下特异性排列进行单价阳离子跨膜运输:K+>Rb+>Cs+>>Na+

生化/生理作用

产物不与ATP竞争。
可逆:否
细胞渗透性:否
首要靶标
破坏膜电位并刺激线粒体中的ATP酶活性。

警告

毒性:有毒(F)

重悬

在重悬后分装并冻存。储备液可在-20°C稳定1个月。

其他说明

Moriyama, Y., et al. 1994.J. Biochem.115, 213.
Eytan, G.D., et al. 1990.J. Biol. Chem.265, 12949.
Alonso, M.A., and Carrasco, L. 1981.FEBS Lett.127, 112.
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法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2

WGK

WGK 3

法规信息

监管及禁止进口产品

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