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Merck
CN

481975

(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC), Nicotinic acetylcholine receptor agonist, solid

别名:

(--)-Nicotine, Ditartrate, (S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di- d-tartrate, (S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di-d-tartrate

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关于此项目

经验公式（希尔记法）:
C10H14N2 · 2C4H6O6
化学文摘社编号:
65-31-6
分子量:
462.41
MDL number:
MFCD00069368
UNSPSC Code:
12352210
NACRES:
NA.77

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产品名称

(--)-Nicotine, Ditartrate, Potent agonist of the nicotinic acetylcholine receptor.

SMILES string

N1(C(CCC1)c2cnccc2)C.O[C@H]([C@@H](O)C(=O)O)C(=O)O.O[C@H]([C@@H](O)C(=O)O)C(=O)O

InChI

1S/C10H14N2.2C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t;2*1-,2-/m.11/s1

InChI key

RFEJUZJILGIRHQ-WBPXWQEISA-N

description

Merck USA index - 14, 6524

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

ethanol: 10 mg/mL
water: 10 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

相关类别

Biochem/physiol Actions

Cell permeable: no
Primary Target
Nicotinic acetylcholine receptor
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Highly Toxic (H)

General description

Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Rand, M.J. 1989. Prog. Brain Res. 79, 3.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

flash_point_f

289.8 °F

flash_point_c

143.2 °C

法规信息

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Yan Wang et al.
Oncology reports, 40(4), 2097-2104 (2018-07-18)
Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was

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