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Merck
CN
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主要文件

479975

Sigma-Aldrich

NDGA

A cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC₅₀ = 200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC₅₀ = 100 µM).

别名:

NDGA, Nordihydroguaiaretic Acid

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About This Item

经验公式（希尔记法）:
C18H22O4
CAS号:
500-38-9
分子量:
302.36
MDL编号:
MFCD00002206
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥90% (HPLC)

表单

crystalline solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

溶解性

DMSO: 10 mg/mL
ethanol: soluble

运输

ambient

储存温度

10-30°C

SMILES字符串

Oc1c(ccc(c1)C[C@H]([C@H](Cc2cc(c(cc2)O)O)C)C)O

InChI

1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+

InChI key

HCZKYJDFEPMADG-TXEJJXNPSA-N

一般描述

A cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss/3T3 cells. A powerful hydroxy radical quencher.
A cell-permeable, antioxidant and a selective lipoxygenase (LO) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LO, 12-LO, and 15-LO, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss 3T3 cells.

生化/生理作用

Cell permeable: yes
Primary Target
LOX-5
Product does not compete with ATP.
Reversible: no
Target IC50: 200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Domin, J., et al. 1994. J. Biol. Chem. 269, 8260.
Goodman, Y., et al. 1994. Brain Res. 654, 171.
Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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