476485
PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化
PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (Ki = 36 nM).
别名:
PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C53H100N20O12
分子量:
1209.49
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
质量水平
方案
≥95% (HPLC)
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
溶解性
water: 1 mg/mL
运输
ambient
储存温度
−20°C
一般描述
热稳定的蛋白激酶抑制剂（PKI）肽序列（14-22），在N端已被肉豆蔻酰化，增强了其细胞通透性。该肽的非肉豆蔻酰化形式是cAMP依赖性蛋白激酶的高度特异性抑制剂（Ki=36 nM）。
热稳定的蛋白激酶抑制剂（PKI）肽序列（14-22），在N端已被肉豆蔻酰化，增强了其细胞通透性。该肽的非肉豆蔻酰化形式是cAMP依赖性蛋白激酶（PKA）的高度特异性抑制剂（Ki=36 nM）。
生化/生理作用
主要靶标
cAMP依赖性蛋白激酶
cAMP依赖性蛋白激酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标Ki：36 nMf或cAMP依赖性蛋白激酶
警告
毒性：标准处理（A）
序列
Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
外形
作为三氟乙酸盐提供。
重悬
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他说明
Paman, K., et al. 1998.J. Lipid Res. 39, 1091.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Duomeng Yang et al.
Communications biology, 5(1), 96-96 (2022-01-27)
Intrinsic cardiac adrenergic (ICA) cells regulate both developing and adult cardiac physiological and pathological processes. However, the role of ICA cells in septic cardiomyopathy is unknown. Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation
Akiko Nakayama et al.
JCI insight, 5(23) (2020-12-04)
Atherosclerosis develops preferentially in areas of the arterial system, in which blood flow is disturbed. Exposure of endothelial cells to disturbed flow has been shown to induce inflammatory signaling, including NF-κB activation, which leads to the expression of leukocyte adhesion
Lingdi Nie et al.
Cells, 11(21) (2022-11-12)
The communication between calcitonin gene-related peptide (CGRP) and cytokines plays a prominent role in maintaining trigeminal ganglion (TG) and trigeminovascular sensitization. However, the underlying regulatory mechanism is elusive. In this study, we explored the hypothesis that Src family kinases (SFKs)
Lian-Pan Wu et al.
Acta pharmacologica Sinica, 41(1), 34-46 (2019-09-14)
Abnormal growth of the intimal layer of blood vessels (neointima formation) contributes to the progression of atherosclerosis and in-stent restenosis. Recent evidence shows that the 18-kDa translocator protein (TSPO), a mitochondrial membrane protein, is involved in diverse cardiovascular diseases. In
Lukasz Buldak et al.
Journal of applied biomedicine, 20(4), 130-140 (2023-01-29)
Statins are primary drugs in the treatment of hyperlipidemias. This group of drugs is known for its beneficial pleiotropic effects (e.g., reduction of inflammatory state). However, a growing body of evidence suggests its diabetogenic properties. The culpable mechanism is not
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门