475989
噻唑蓝四唑蓝
Membrane-permeable yellow dye that is reduced by mitochondrial reductases in living cells to form the dark blue product, MTT-formazan.
别名:
噻唑蓝四唑蓝, 3-（4，5-二甲基-2-噻唑）-2,5-二苯基-2H-溴化四唑噻唑蓝
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关于此项目
经验公式（希尔记法）:
C18H16BrN5S
化学文摘社编号:
分子量:
414.32
UNSPSC Code:
12171500
NACRES:
NA.25
MDL number:
产品名称
噻唑蓝四唑蓝, Membrane-permeable yellow dye that is reduced by mitochondrial reductases in living cells to form the dark blue product, MTT-formazan.
SMILES string
[s]1c(nc(c1C)C)[n]2[n+](nc(n2)c4ccccc4)c3ccccc3.[Br-]
InChI
1S/C18H16N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3;1H/q+1;/p-1
InChI key
AZKSAVLVSZKNRD-UHFFFAOYSA-M
description
RTECS - XF8060000
assay
≥98% (silver nitrate titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤0.5% Sulfated ash
color
yellow
solubility
PBS: 2 mg/mL
cation traces
heavy metals: ≤0.001%
shipped in
ambient
storage temp.
15-25°C
Quality Level
Biochem/physiol Actions
主要靶标
用作细胞毒性和凋亡的直接指标。
用作细胞毒性和凋亡的直接指标。
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
Disclaimer
毒性：有害 & 致癌/致畸性（E）
General description
一种膜渗透性黄色染料，在活细胞中被线粒体还原酶还原形成深蓝色产物MTT-甲臜。MTT-甲臜在540或570 nm处的分光光度测量可定量细胞活力。用作细胞毒性（如用于筛选癌症药物）和凋亡的直接指标。一种用于研究NADP依赖性脱氢酶类的电子受体。
Other Notes
Liu, Y., et al. 1997.J. Neurochem.69, 581.
Abdallah, M.A. 1980.Eur. J. Biochem.112, 331.
Abdallah, M.A. 1980.Eur. J. Biochem.112, 331.
Preparation Note
复溶后，分装并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多1个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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