475981
Myosin Light Chain Kinase Inhibitor Peptide 18
The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Myosin Light Chain Kinase Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor Peptide 18, MLCK Inhibitor IV, MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV
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所有图片(1)
About This Item
经验公式（希尔记法）:
C60H105N23O11
分子量:
1324.62
UNSPSC代码:
12352202
NACRES:
NA.77
质量水平
检测方案
≥97% (HPLC)
形式
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
water: 1 mg/mL
DMSO: 5 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
A highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP.
A highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
生化/生理作用
Cell permeable: yes
Primary Target
Mlck
Mlck
Product does not compete with ATP.
Reversible: no
Target IC50: 50 nM against MLCK
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Zolotarevsky, Y., et al. 2002. Gastroenterology123, 163.
Lukas, T.J., et al. 1999. J. Med. Chem.42, 910.
Lukas, T.J., et al. 1999. J. Med. Chem.42, 910.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Nicholas J Hunt et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 75(2), 278-285 (2019-06-15)
Age-related changes in the liver sinusoidal endothelium, particularly the reduction in fenestrations, contribute to insulin resistance in old age. Metformin impacts on the aging process and improves insulin resistance. Therefore, the effects of metformin on the liver sinusoidal endothelium were
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