475956
c-Myc抑制剂
≥95% (sum of two isomers, HPLC), c-Myc-Max interaction inhibitor, solid
别名:
c-Myc抑制剂, 10058-F4，（Z，E）-5-（4-乙基苄基）-2-硫代噻唑烷-4-酮
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关于此项目
经验公式（希尔记法）:
C12H11NOS2
化学文摘社编号:
分子量:
249.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (sum of two isomers, HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze
protect from light
protect from light
产品名称
c-Myc抑制剂, The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.
SMILES string
S1\C(=C\c2ccc(cc2)CC)\C(=O)NC1=S
InChI
1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
InChI key
SVXDHPADAXBMFB-JXMROGBWSA-N
assay
≥95% (sum of two isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
主要靶标
c-Myc
c-Myc
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
Disclaimer
毒性：致癌/致畸（D）
General description
一种可渗透细胞的噻唑烷酮化合物，可特异性抑制c-Myc-Max相互作用，从而阻止c-Myc靶向基因表达的反式激活。显示在体外和体内均以c-Myc依赖性方式抑制肿瘤细胞生长（64 μM，使用c-Myc转染的大鼠1a成纤维细胞）。
一种可渗透细胞的噻唑烷酮化合物，可特异性抑制c-Myc-Max相互作用，从而阻止c-Myc靶向基因表达的反式激活。显示在体外和体内均以c-Myc依赖性方式抑制肿瘤细胞生长（有效浓度：64 µM，使用c-Myc转染的大鼠1a成纤维细胞）。
Legal Information
根据美国专利号7,026,343的许可证销售。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Yin, X., et al. 2003.Oncogene22, 6151.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Andrea Arena et al.
Biomedicines, 10(4) (2022-04-24)
Multiple myeloma (MM) and primary effusion lymphoma (PEL) are aggressive hematological cancers, for which the search for new and more effective therapies is needed. Both cancers overexpress c-Myc and are highly dependent on this proto-oncogene for their survival. Although c-Myc
Roberta Gonnella et al.
Cancers, 15(23) (2023-12-09)
Heat shock proteins (HSPs) are highly expressed in cancer cells and represent a promising target in anti-cancer therapy. In this study, we investigated for the first time the expression of high-molecular-weight HSP110, belonging to the HSP70 family of proteins, in
Le Tran Phuc Khoa et al.
Nature communications, 15(1), 1721-1721 (2024-02-27)
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo.
Wei Fan et al.
eLife, 10 (2021-05-28)
Sphingolipids are important structural components of cell membranes and prominent signaling molecules controlling cell growth, differentiation, and apoptosis. Sphingolipids are particularly abundant in the brain, and defects in sphingolipid degradation are associated with several human neurodegenerative diseases. However, molecular mechanisms
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