475882-M
ML-9, Hydrochloride
A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM).
别名:
ML-9, Hydrochloride, 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
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关于此项目
经验公式（希尔记法）:
C15H17ClN2O2S · xHCl
化学文摘社编号:
分子量:
324.83 (free base basis)
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
SMILES string
[S](=O)(=O)(N3CCNCCC3)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
InChI
1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
ZNRYCIVTNLZOGI-UHFFFAOYSA-N
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
50% ethanol: 10 mg/mL
storage temp.
2-8°C
Quality Level
General description
A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
Biochem/physiol Actions
Primary Target
Mlck
Mlck
Target Ki: 3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Further dilute with aqueous buffer just prior to use.
Other Notes
Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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