product name
MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
质量水平
检测方案
≥95% (TLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
protect from light
颜色
brown
溶解性
aqueous base: soluble
运输
ambient
储存温度
−20°C
一般描述
细胞可渗透的超氧化物歧化酶（SOD）模拟物和过氧亚硝酸盐清除剂。以剂量依赖性方式（EC50 ~40 µ M）保护内皮细胞免受百草枯（2 mM）的侵害。抑制过氧亚硝酸盐对二氢罗丹明-123的氧化，但不清除一氧化氮（NO）。
细胞可渗透的超氧化物歧化酶（SOD）模拟物和过氧亚硝酸盐清除剂。以剂量依赖性方式（EC50 ~40 µ M）保护内皮细胞免受百草枯（2 mM）的侵害。抑制过氧亚硝酸盐对二氢罗丹明123（目录号309825）的氧化，但不清除一氧化氮（NO）。
生化/生理作用
主要靶标
超氧化物歧化酶（SOD）模拟物
超氧化物歧化酶（SOD）模拟物
产物不与ATP竞争。
保护内皮细胞免受百草枯（2 mM）侵害的EC50 ~40 µM
可逆：否
细胞可渗透性：具有
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多6个月。
其他说明
Aladag, M. A., et al. 2003.Acta Neurochir.145, 673.
Szabo, C., et al. 1996.FEBS Lett.381, 82.
Day, B.J., et al. 1995.J. Pharmacol.Exp.Ther.275, 1227.
Faulkner, K.M., et al. 1994.J. Biol. Chem. 269, 23471.
Szabo, C., et al. 1996.FEBS Lett.381, 82.
Day, B.J., et al. 1995.J. Pharmacol.Exp.Ther.275, 1227.
Faulkner, K.M., et al. 1994.J. Biol. Chem. 269, 23471.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
B J Day et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1227-1232 (1995-12-01)
There is an increased interest in development of therapeutic agents to treat disease states that involve reactive oxygen species in their pathophysiology. The metalloporphyrins, MnTBAP and ZnTBAP, were found to be active in a superoxide dismutase (SOD) assay. The efficacy
K M Faulkner et al.
The Journal of biological chemistry, 269(38), 23471-23476 (1994-09-23)
Several manganic porphyrins, with substituents on the methine bridge carbons, were prepared and examined for stability, redox behavior, catalysis of the dismutation of superoxide radical (O2-), and the ability to protect a superoxide dismutase (SOD)-null strain of E. coli against
C Szabó et al.
FEBS letters, 381(1-2), 82-86 (1996-02-26)
Here we report that the cell-permeable superoxide dismutase mimetic Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP) inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO). MnTBAP protects against the suppression of mitochondrial respiration in J774 cells exposed
M A Aladag et al.
Acta neurochirurgica, 145(8), 673-677 (2003-10-02)
Delayed cerebral vasoconstriction and brain ischemia, are critical problems in the management of a patient affected by rupture of an intracranial aneurysm. Overexpression of Cu-Zn superoxide dismutase (Cu-Zn SOD) can reduce the extent of cerebral vasospasm. We, therefore investigated if
Maria Catalina Gomez-Puerto et al.
International journal of molecular sciences, 21(11) (2020-06-14)
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by obstructed pulmonary vasculatures. Current therapies for PAH are limited and only alleviate symptoms. Reduced levels of BMPR2 are associated with PAH pathophysiology. Moreover, reactive oxygen species, inflammation and autophagy have
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