475856
Mdivi-1
≥95% (HPLC), dynamin-related GTPases inhibitor, solid
别名:
线粒体分裂抑制剂，mdivi-1
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关于此项目
经验公式（希尔记法）:
C15H10Cl2N2O2S
化学文摘社编号:
分子量:
353.22
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
线粒体分裂抑制剂，mdivi-1, The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
Sc1[n]([c](c3c(n1)cccc3)=O)c2c(cc(c(c2)OC)Cl)Cl
InChI
1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChI key
NZJKEVWTYMOYOR-UHFFFAOYSA-N
General description
一种可渗透细胞的喹唑啉酮化合物，可抑制酵母（Dnm1）和哺乳动物（Drp1）分裂DRP（与发动蛋白相关的GTPases），并以可逆的方式有效诱导线粒体融合成网状结构（在酵母和COS培养物中IC50分别为10和50 M）。无细胞研究表明，mdivi-1通过基于变构调节的机制阻断Dnm1 ATP酶活性（IC50<10 M）和自组装。通过细胞色素C释放评估，Mdivi-1分别在HeLa培养物和无细胞鼠肝线粒体制剂中有效抑制STS和C8-Bid诱导的MOMP（线粒体外膜通透性）。
Packaging
用惰性气体包装
Other Notes
Cassidy-Stone A., et al. 2008.Dev.Cell14, 193.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Henna Myllymäki et al.
Oncogenesis, 13(1), 7-7 (2024-01-26)
Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [1, 2]. Since then, the 'Warburg effect' has been widely accepted as a key feature of rapidly
Ann Cassidy-Stone et al.
Developmental cell, 14(2), 193-204 (2008-02-13)
Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from mitochondria, in part by controlling cristae structures. Mitochondrial division promotes apoptosis by an unknown mechanism. We
Afzal Misrani et al.
Frontiers in aging neuroscience, 13, 748388-748388 (2021-12-28)
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Mitochondrial dysfunction is thought to be an early event in the onset and progression of AD; however, the precise underlying mechanisms remain unclear. In this study, we investigated mitochondrial proteins
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 475856-10MG | 07790788056377 |