推荐产品
质量水平
检测方案
≥99% (titration)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
杂质
≤0.1% Steroid substances
颜色
yellow
溶解性
ethanol: 10 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
InChI key
VKHAHZOOUSRJNA-GCNJZUOMSA-N
一般描述
一种可渗透细胞的合成类固醇，作为孕激素和糖皮质激素受体的有效拮抗剂。抑制P-糖蛋白（P-gp）功能并下调P-gp介导的抗药性。显示抗血管生成作用并抑制血管内皮生长因子（VEGF）的产生。调节小鼠子宫内膜中Fas和FasL的表达以及前列腺癌细胞中TRAIL的表达。作为一种抗氧化剂，可提供针对CA1锥体细胞中受控皮层撞击（CCI）的神经保护作用，以及对小鼠海马HT22细胞的Aβ-，H2O2-和谷氨酸诱导性的损伤的神经保护作用。
一种可透过细胞的合成类固醇，作为孕激素和糖皮质激素受体的有效拮抗剂。 据报告可抑制P-糖蛋白（P-gp）功能并下调P-gp介导的抗药性。还显示抗血管生成作用并抑制血管内皮生长因子（VEGF）的产生。显示调节小鼠子宫内膜中Fas和FasL的表达以及前列腺癌细胞中TRAIL的表达。作为一种抗氧化剂，据报告可提供针对CA1锥体细胞中受控皮层撞击（CCI）的神经保护作用，以及对小鼠海马HT22细胞的Aβ-，H2O2-和谷氨酸诱导性的损伤的神经保护作用。
生化/生理作用
主要靶标
孕激素和糖皮质激素受体
孕激素和糖皮质激素受体
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
包装
用惰性气体包装
警告
毒性：致癌/致畸（D）
重悬
复溶后等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他说明
McCullers, D.L., et al. 2002.Neuroscience109, 219.
Sidell, N., et al. 2002.Ann.N. Y. Acad.Sci.955, 159.
Gao, F., et al. 2001.Acta Pharmacol.Sin.22, 524.
Hyder, S.M., et al. 2001.Int. J. Cancer92, 469.
Lam, F.C., et al. 2001.J. Neurochem.76, 1121.
Sridhar, S., et al. 2001.Cancer Res.61, 7179.
Behl, C., et al. 1997.Eur. J. Neurosci.9, 912.
Greb, R.R., et al. 1997.Hum.Reprod.12, 1280.
Gruol, D.J., et al. 1994.Cancer Res.54, 3088.
Sidell, N., et al. 2002.Ann.N. Y. Acad.Sci.955, 159.
Gao, F., et al. 2001.Acta Pharmacol.Sin.22, 524.
Hyder, S.M., et al. 2001.Int. J. Cancer92, 469.
Lam, F.C., et al. 2001.J. Neurochem.76, 1121.
Sridhar, S., et al. 2001.Cancer Res.61, 7179.
Behl, C., et al. 1997.Eur. J. Neurosci.9, 912.
Greb, R.R., et al. 1997.Hum.Reprod.12, 1280.
Gruol, D.J., et al. 1994.Cancer Res.54, 3088.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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