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474787

Sigma-Aldrich

MG-132

≥95% by HPLC, Potent, reversible, and cell-permeable proteasome inhibitor (Kᵢ = 4 nM).

别名:

Z-Leu-Leu-Leu-al, MG-132

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About This Item

经验公式（希尔记法）:
C26H41N3O5
CAS号:
133407-82-6
分子量:
475.62
MDL编号:
MFCD00674886
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

MG-132，HPLC检测显示纯度≥95%, Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).

质量水平

100

方案

≥95% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 25 mg/mL
ethanol: 25 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

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Amino Acid Sequence

Z-Leu-Leu-Leu-al

一般描述

高效、可逆和细胞渗透性蛋白酶体抑制剂抑制剂 (Ki = 4 nM)。通过26S复合物减少哺乳动物细胞和酵母的可渗透染色中泛素结合蛋白的降解，而不会影响其ATPase或异肽酶的活性。活化可启动细胞凋亡的c-Jun N-端激酶（JNK1）抑制NF-κB激活（IC50 = 3µM）。该材料经HPLC测试为≥95%纯。 还可提供经HPLC测试为≥98%纯（货号474790）的材料。
高效、可逆和细胞渗透性蛋白酶体抑制剂抑制剂 (Ki = 4 nM)。通过26S复合物减少哺乳动物细胞和酵母的可渗透染色中泛素结合蛋白的降解，而不会影响其ATPase或异肽酶的活性。活化可启动细胞凋亡的c-Jun N-端激酶（JNK1）抑制NF-κB激活（IC50 = 3µM）。该材料经HPLC测试为≥95%纯。 还可提供经HPLC测试为≥98%纯（货号474790）的材料。还可以提供在DMSO（货号474788）中的20 mM溶液。

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Steinhilb, M.L., et al. 2001.J. Biol. Chem.276, 4476.
Meriin, A.B., et al. 1998.J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Klafki, H.W., et al. 1996.J. Biol. Chem.271, 2865.
Lee, D.H., and Goldberg, A.L., 1996.J. Biol. Chem.271, 27280.
Wiertz, E.J., et al. 1996.Cell84, 769.
Jensen, T.J., et al. 1995.Cell 83, 129.
Read, M.A., et al. 1995.Immunity2, 493.
Rock, K.L., et al. 1994.Cell 78, 761.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

分析证书(COA)

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A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We detected a
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