推荐产品
质量水平
方案
≥98% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
ethanol: 20 mg/mL
DMSO: 30 mg/mL
运输
ambient
储存温度
−20°C
一般描述
Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.
Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G1 phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).
生化/生理作用
Cell permeable: no
Primary Target
HMG-CoA reductase
HMG-CoA reductase
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.
Endo, A. 1992. J. Lipid Res.33, 1569.
Endo, A. 1992. J. Lipid Res.33, 1569.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mouhannad Malek et al.
Nature communications, 12(1), 2673-2673 (2021-05-13)
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. Here we reveal a
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