跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

459618

Sigma-Aldrich

Okadaic Acid potassium salt

≥95% (HPLC), solid, protein phosphatase 2A and protein phosphatase 1 inhibitor, Calbiochem®

别名:

Okadaic Acid, Potassium Salt

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C44H67O13 · K
CAS号:
155751-72-7
分子量:
843.09
MDL编号:
MFCD00214356
UNSPSC代码:
12352106
NACRES:
NA.77

产品名称

Okadaic Acid, Potassium Salt, Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.

质量水平

100

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

water: 1 mg/mL
DMSO: 20 mg/mL
ethanol: 20 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

[K+].[O-]C(=O)C(O)(CC1OC2(OC(CC(=C2)C)C(C)C=CC3OC4(OC5C(OC(C(=C)C5O)C(O)CC(C6OC7(OCCCC7)CCC6C)C)CC4)CC3)C(CC1)O)C

InChI

1S/C44H68O13.K/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);/q;+1/p-1

InChI key

UXRQUXBFVICHQJ-UHFFFAOYSA-M

一般描述

Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.

生化/生理作用

Cell permeable: no
Primary Target
PP1, PP2
Product does not compete with ATP.
Reversible: no
Target IC50: 10-15 nM, 0.1 nM, against protein phosphatase 1 and protein phosphatase 2A, respectively

警告

Toxicity: Toxic (F)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Gjertsen, B.T., et al. 1994. J. Cell Sci.107, 3363.
Kiguchi, K., et al. 1994. Cell Growth Differ.5, 995.
Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun.189, 950.
Kreienbuhl, P., et al. 1992. Blood80, 2911.
Nomura, M., et al. 1992. Biochemistry31, 11915.
Song, Q., et al. 1992. J. Cell Physiol.153, 550.
Tada, Y., et al. 1992. Immunopharmacol.24, 17.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Andrés Vicente-Acosta et al.
Journal of neuroinflammation, 19(1), 93-93 (2022-04-14)
Friedreich's ataxia is a rare hereditary neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Similar to other neurodegenerative pathologies, previous studies suggested that astrocytes might contribute to the progression of the disease. To fully understand the mechanisms
Irene Benito-Cuesta et al.
Autophagy, 17(3), 656-671 (2020-02-23)
The physiological AKT-MTORC1 and AMPK signaling pathways are considered key nodes in the regulation of anabolism-catabolism, and particularly of macroautophagy/autophagy. Indeed, it is reported that these are altered processes in neurodegenerative proteinopathies such as Alzheimer disease (AD), mainly characterized by

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门