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Merck
CN
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主要文件

454863

Sigma-Aldrich

D-erythro-MAPP

A synthetic analog of ceramide.

别名:

D-erythro-MAPP, (1S,2R)-D- erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP, (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP

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About This Item

经验公式（希尔记法）:
C23H39NO2
CAS号:
143492-38-0
分子量:
361.56
UNSPSC代码:
12352211

质量水平

100

方案

≥98% (NMR)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

溶解性

ethanol: 5 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-16-19-22(25)24-20(2)23(26)21-17-14-13-15-18-21/h13-15,17-18,20,23,26H,3-12,16,19H2,1-2H3,(H,24,25)/t20-,23-/m1/s1

InChI key

YLAZEWZHIRBZDA-NFBKMPQASA-N

一般描述

A synthetic analog of ceramide. Shown to selectively inhibit alkaline ceramidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramidase versus IC50 >500 µM for acid ceramidase). This inhibition results in over 3-fold increase in endogenous ceramide in treated cells due to lack of breakdown of ceramide to sphingosine.
A synthetic analog of ceramide. Shown to selectively inhibit alkaline ceraminidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramides versus IC50 >500 µM for acid ceraminidase). This inhibition results in and over 3-fold increase in endogenous ceramide in treated cells due to a lack of breakdown of ceramide to sphingosine.

生化/生理作用

Cell permeable: yes
Primary Target
Alkaline ceramidase
Product does not compete with ATP.
Reversible: no
Target IC50: 1-5 µM for alkaline ceramidase versus >500 µM for acid ceramidase

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Bielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
Hannun, Y.A. 1996. Science274, 1855.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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