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Merck
CN
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主要文件

445800

Sigma-Aldrich

Merbarone

≥95% (HPLC), solid, topoisomerase II inhibitor, Calbiochem®

别名:

Merbarone, 5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628

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25 MG
CN¥1,956.58

CN¥1,956.58

预计发货时间June 16, 2025详情

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25 MG
CN¥1,956.58

About This Item

经验公式（希尔记法）:
C11H9N3O3S
CAS号:
97534-21-9
分子量:
263.27
MDL编号:
MFCD00866337
UNSPSC代码:
12352200
NACRES:
NA.77

CN¥1,956.58

预计发货时间June 16, 2025详情

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产品名称

Merbarone, A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes.

质量水平

100

描述

RTECS - UV7714625

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

faint pink

溶解性

DMSO: 100 mg/mL

运输

ambient

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此商品
M2070178488189497
Merbarone A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes.

445800

Merbarone

Merbarone ≥98% (HPLC), solid

M2070

Merbarone

Apoptosis Inhibitor The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

178488

Apoptosis Inhibitor

Autophagy Inducer, STF-62247 A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

189497

Autophagy Inducer, STF-62247

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 100 mg/mL

solubility

DMSO: >5 mg/mL

solubility

DMSO: 100 mg/mL, ethanol: 20 mg/mL

solubility

DMSO: 50 mg/mL

一般描述

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topo II versus IC50 = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
A cell-permeable, anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topoisomerase II versus IC50 ~200 µM for topoisomerase I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

生化/生理作用

Cell permeable: yes
Primary Target
Catalytic activity of topoisomerase II
Product does not compete with ATP.
Reversible: no
Target IC50: 20 µM for purified topoisomerase II (topo II)

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Khelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
Drake, F.H., et al. 1989. Cancer Res.49, 2578.
Brewer, A.D., et al. 1985. Biochem. Pharmacol.34, 2047.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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    Nootan Pandey et al.
    The Journal of cell biology, 219(1) (2019-11-13)
    Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing additional

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