推荐产品
产品名称
MMP-12抑制剂，MMP408, The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
质量水平
方案
≥94% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
一种二苯并呋喃基磺酰胺基缬氨酸化合物，可作为有效的活性位点锌靶向MMP-12选择性抑制剂（对人MMP-12的IC50 =2 nM），对小鼠/大鼠/绵羊物种的MMP-12（分别为IC50=160、320和22.3 nM）或人MMP-3/13/14（分别为IC50=351、120和1100 nM）的活性弱得多，并且对人Agg-1/2（IC50 >5 µM），TACE（IC50 >25 µM）和MMP-1/7（IC50 >6 µM）几乎无效。MMP408在小鼠中具有口服活性，并显示可有效减轻rhMMP-12诱导的小鼠体内肺组织炎症反应超过50%（5 mg/kg，p.o.，b.i.d.）。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他说明
Li, W., et al. 2009.J. Med. Chem.52, 1799.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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