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Merck
CN

444283

MMP-13抑制剂

The MMP-13 Inhibitor, also referenced under CAS 544678-85-5, controls the biological activity of MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

MMP-13抑制剂, 嘧啶-4，6-二羧酸，双-（4-氟-3-甲基-苄基酰胺）

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关于此项目

经验公式（希尔记法）:
C22H20F2N4O2
化学文摘社编号:
544678-85-5
分子量:
410.42
MDL number:
MFCD09878513
UNSPSC Code:
12352200
NACRES:
NA.77

主要文件

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产品名称

MMP-13抑制剂, The MMP-13 Inhibitor, also referenced under CAS 544678-85-5, controls the biological activity of MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

SMILES string

Fc1c(cc(cc1)CNC(=O)c2ncnc(c2)C(=O)NCc3cc(c(cc3)F)C)C

InChI

1S/C22H20F2N4O2/c1-13-7-15(3-5-17(13)23)10-25-21(29)19-9-20(28-12-27-19)22(30)26-11-16-4-6-18(24)14(2)8-16/h3-9,12H,10-11H2,1-2H3,(H,25,29)(H,26,30)

InChI key

PYFRREJCFXFNRR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要靶标
MMP-13活性
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：MMP-13为8 nM

Disclaimer

毒性：标准处理（A）

General description

MMP-13活性的强效抑制剂（IC50=8 nM），并通过构象结构分析确定对MMP-1，-2，-3，-7，-8，-9，-10，-12，-14和-16具有预期的选择性。显示与MMP-13催化结构域结合并充当非锌螯合抑制剂。
一种嘧啶二甲酰胺化合物，可有效抑制MMP-13活性（IC50=8 nM），并通过构象结构分析确定对MMP-1，-2，-3，-7，-8，-9，-10，-12，-14和-16具有预期的选择性。显示与MMP-13催化结构域结合并充当非锌螯合抑制剂。

Other Notes

Engel, C.K., et al. 2005.Chem. Biol.12, 181.

Packaging

用惰性气体包装

Preparation Note

使用前立即用缓冲液进一步稀释。
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多6个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Christian K Engel et al.
Chemistry & biology, 12(2), 181-189 (2005-03-01)
Inhibitors for matrix metalloproteinases (MMPs) are under investigation for the treatment of cancer, arthritis, and cardiovascular disease. Here, we report a class of highly selective MMP-13 inhibitors (pyrimidine dicarboxamides) that exhibit no detectable activity against other MMPs. The high-resolution X-ray
Spenser S Smith et al.
eLife, 11 (2022-06-07)
Precise developmental control of jaw length is critical for survival, but underlying molecular mechanisms remain poorly understood. The jaw skeleton arises from neural crest mesenchyme (NCM), and we previously demonstrated that these progenitor cells express more bone-resorbing enzymes including Matrix
Kristina Viiklepp et al.
The Journal of investigative dermatology (2021-11-11)
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer with increasing incidence worldwide. Previous studies have demonstrated the role of complement system in cSCC progression. In this study we have investigated the mechanistic role of serine protease

相关内容

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