444249
基质金属蛋白酶MMP-2/MMP-9抑制剂II
The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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别名:
基质金属蛋白酶MMP-2/MMP-9抑制剂II, （2R）-[（4-联苯磺酰基）氨基]-N-羟基-3-苯基丙酰胺，BiPS，BiPS
经验公式（希尔记法）:
C21H20N2O4S
推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
off-white
溶解性
DMSO: 100 mg/mL
methanol: 25 mg/mL
运输
ambient
储存温度
−20°C
一般描述
IV型胶原酶的有效抑制剂，MMP-2（IC50=17 nM）和MMP-9（IC50=30 nM）。还显示出可以有效诱导并快速激活HIF。已显示在鼠模型中体内抑制Lewis肺癌诱导的肺定植。
MMP-2（IC50=17 nM）和MMP-9（IC50=30 nM）的有效抑制剂。还显示出可以有效诱导并快速激活HIF。据报告在鼠模型中抑制Lewis肺癌诱导的肺定植。
生化/生理作用
主要靶标
MMP-2
MMP-2
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：MMP-2和MMP-9分别为17 nM和30 nM
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多6个月。
其他说明
Lauzier, M.C., et al. 2008.Mol.Pharmacol.In press.
Mifune, M., et al. 2005.J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004.Circ.Res.95, 989.
Tamura, Y., et al. 1998.J. Med. Chem.41, 640.
Mifune, M., et al. 2005.J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004.Circ.Res.95, 989.
Tamura, Y., et al. 1998.J. Med. Chem.41, 640.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
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