444247
MMP Inhibitor II
The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
MMP Inhibitor II, N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
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About This Item
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质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
off-white
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C21H27N3O8S2/c1-21(2)13-23(33(27,28)17-9-5-15(31-3)6-10-17)20(19(25)22-26)24(14-21)34(29,30)18-11-7-16(32-4)8-12-18/h5-12,20,26H,13-14H2,1-4H3,(H,22,25)
InChI key
MCSWSPNUKWMZHM-UHFFFAOYSA-N
一般描述
A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
A potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Target IC50: 24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
制备说明
Requires vigorous vortexing for 60 seconds to completely solubilize the product.
其他说明
Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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