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442630-M

Sigma-Aldrich

GMBS

别名:

GMBS, N-γ-Maleimidobutyryloxysuccinimide

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About This Item

经验公式（希尔记法）:
C12H12N2O6
CAS号:
80307-12-6
分子量:
280.23
MDL编号:
MFCD00036817
UNSPSC代码:
12161500
NACRES:
NA.24

方案

≥90% (HPLC)

质量水平

100

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

储存温度

−20°C

SMILES字符串

N2(C(=O)CCC2=O)OC(=O)CCCN1C(=O)C=CC1=O

InChI

1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2

InChI key

PVGATNRYUYNBHO-UHFFFAOYSA-N

一般描述

Heterobifunctional reagent useful for preparation of conjugates such as secondary antibodies and β-galactosidase for EIA procedures or for immobilizing enzymes on solid supports.
N-γ-maleimidobutyryloxysuccinimide ester (GMBS) is an aliphatic crosslinker for immunotoxins (IT).(1) It is used for the generation of conjugated Poly-γ-D-glutamic acid.

应用

GMBS is suitable for use:
  • as a hetero-bifunctional cross-linking reagent for the immobilization of neural adhesion molecule L1 onto silicon dioxide surface
  • for the crosslinking of biochips with functionalized gold nanoparticles
  • for coating salinized capillary tube prior to neutravidin treatment in biosensor sandwich immunoassay

警告

Toxicity: Irritant (B)

重悬

Reconstitute to 10 mg/ml in tetrahydrofuran or DMSO. Add 1 ml of this stock solution dropwise, with stirring, to 10 ml of 20 mM phosphate buffer.

其他说明

Rusin, K.M., et al. 1992. Biosens. Bioelectron. 7, 367.
Kitagawa, T., et al. 1983. J. Biochem. 94, 1160.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Detection of water-borne E. coli O157 using the integrating waveguide biosensor
<BIG>Zhu P, et al</BIG>
Biosensors And Bioelectronics, 21, 678-683 (2005)
Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization
Acta Biomaterialia, 4, 1208-1217 (2008)
Biomolecules detection using a silver-enhanced gold nanoparticle-based biochip
<BIG>Liu Y, et al</BIG>
Nanoscale Research Letters, 5, 533-533 (2010)
Poly-gamma-D-glutamic acid and protective antigen conjugate vaccines induce functional antibodies against the protective antigen and capsule of Bacillus anthracis in guinea-pigs and rabbits
<BIG>Lee DY, et al</BIG>
FEMS Immunology and Medical Microbiology, 57, Lee DY-Lee DY (2009)

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