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Merck
CN
所有图片(1)

主要文件

440204

Sigma-Aldrich

LY 294002

InSolution, ≥98%, 10 mM, reversible and specific inhibitor of PI 3-kinase

别名:

InSolution LY 294002, 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

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About This Item

经验公式(希尔记法):
C19H17NO3
分子量:
307.34
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

运输

wet ice

储存温度

−20°C

SMILES字符串

N4(CCOCC4)c1[o]c2c([c](c1)=O)cccc2c3ccccc3

InChI

1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2

InChI key

CZQHHVNHHHRRDU-UHFFFAOYSA-N

生化/生理作用

Cell permeable: yes
Primary Target
phosphatidylinositol 3-kinase
Product competes with ATP.
Reversible: yes
Target IC50: 1.4 µM against phosphatidylinositol 3-kinase

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Dittman, A., et al. 2013. ACS Chem. Biol.9, 495.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA95, 14066.
Cardone, M.H., et al. 1998. Science282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol.154, 2413.
Yano, H., et al. 1995. Biochem. J.312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem.269, 5241.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.


法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - (refers to pure substance)

闪点(°C)

87 °C - (refers to pure substance)


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