推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
amber
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2
InChI key
NGAGMBNBKCDCDJ-UHFFFAOYSA-N
一般描述
A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM).
A cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.
生化/生理作用
Cell permeable: yes
Primary Target
Negative control for the PI 3-kinase inhibitor LY 294002
Negative control for the PI 3-kinase inhibitor LY 294002
Product does not compete with ATP.
Reversible: no
Target IC50: Does not inhibit PI 3-kinase even at a concentration of 100 µM
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Dittman, et al. 2014. ACS Chem Biol.9, 495.
Ding, J., et al. 1995. J. Biol. Chem.270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
Ding, J., et al. 1995. J. Biol. Chem.270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门