434610
Leukadherin-1
A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.
别名:
Leukadherin-1, αMβ2 Agonist II, CD11b Agonist II, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid
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About This Item
推荐产品
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
red-brown
溶解性
DMSO: 5 mg/mL, yellow
运输
ambient
储存温度
2-8°C
SMILES字符串
O=C(/C(S1)=C/C2=CC=C(C3=CC=C(C=C3)C(O)=O)O2)N(CC4=CC=CC=C4)C1=S
InChI key
AEZGRQSLKVNPCI-UNOMPAQXSA-N
一般描述
A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models in vivo, including thioglycolate-induced peritonitis (10 nmol/0.2 ml/mouse; i.v.), anti-GBM-induced nephritis (25 nmol/0.5 ml/mouse; i.p.), balloon-induced artery injury (50 nmol/1 ml/rat; i.m.), and zebrafish tailfin injury.CR3
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Maiguel, D., et al. 2011. Sci. Signal.4, ra57.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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