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Merck
CN

428021

Latrunculin A

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem

别名:

红海海绵素A，来源于Latrunculia magnifica

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关于此项目

经验公式（希尔记法）:
C22H31NO5S
化学文摘社编号:
76343-93-6
分子量:
421.55
MDL number:
MFCD27977552
UNSPSC Code:
12352200
NACRES:
NA.77

主要文件

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产品名称

红海海绵素A，来源于Latrunculia magnifica, Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (KD = 200 nM).

SMILES string

S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C\C=C/[C@H](CC3)C)\C)C2)O

InChI

1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1

InChI key

DDVBPZROPPMBLW-IZGXTMSKSA-N

description

Merck USA index - 14, 8378

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

与单体G-肌动蛋白形成1：1复合物中Kd=200 nM
主要靶标
G-肌动蛋白
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有

Disclaimer

毒性：有害（C）

General description

一种可渗透细胞的海洋毒素，通过与单体G-肌动蛋白（Kd=200 nM）形成1：1的复合物来破坏培养细胞中的微丝组织。也是精子，卵子和胚胎中微丝介导过程的有效抑制剂。1 mM（50 µg/119µ l）的Latrunculin A，Latrunculia magnifica目录号 428026的DMSO溶液也可用。
来自红海海绵Latrunculia magnifica的可渗透细胞的海洋毒素，通过与单体G-肌动蛋白（Kd=200 nM）形成1：1的复合物来破坏培养细胞中的微丝组织。也是精子，卵子和胚胎中微丝介导过程的有效抑制剂。

Other Notes

Ayscough, K.R., et al. 1997.J. Cell Biol. 137, 399.
Spector, I., et al. 1989.Cell Motil.Cytoskeleton 13, 127.
Coue, M., et al. 1987.FEBS Lett.213, 316.
Schatten, G., et al. 1986.Exp.Cell Res. 166, 191.
Spector, I., et al. 1983.Science 219, 493.

Packaging

用惰性气体包装

Preparation Note

复溶后等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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