product name
红海海绵素A，来源于Latrunculia magnifica, Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (KD = 200 nM).
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 25 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
InChI key
DDVBPZROPPMBLW-IZGXTMSKSA-N
一般描述
一种可渗透细胞的海洋毒素，通过与单体G-肌动蛋白（Kd=200 nM）形成1：1的复合物来破坏培养细胞中的微丝组织。也是精子，卵子和胚胎中微丝介导过程的有效抑制剂。1 mM（50 µg/119µ l）的Latrunculin A，Latrunculia magnifica目录号 428026的DMSO溶液也可用。
来自红海海绵Latrunculia magnifica的可渗透细胞的海洋毒素，通过与单体G-肌动蛋白（Kd=200 nM）形成1：1的复合物来破坏培养细胞中的微丝组织。也是精子，卵子和胚胎中微丝介导过程的有效抑制剂。
生化/生理作用
与单体G-肌动蛋白形成1：1复合物中Kd=200 nM
主要靶标
G-肌动蛋白
G-肌动蛋白
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
包装
用惰性气体包装
警告
毒性：有害（C）
重悬
复溶后等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他说明
Ayscough, K.R., et al. 1997.J. Cell Biol. 137, 399.
Spector, I., et al. 1989.Cell Motil.Cytoskeleton 13, 127.
Coue, M., et al. 1987.FEBS Lett.213, 316.
Schatten, G., et al. 1986.Exp.Cell Res. 166, 191.
Spector, I., et al. 1983.Science 219, 493.
Spector, I., et al. 1989.Cell Motil.Cytoskeleton 13, 127.
Coue, M., et al. 1987.FEBS Lett.213, 316.
Schatten, G., et al. 1986.Exp.Cell Res. 166, 191.
Spector, I., et al. 1983.Science 219, 493.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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