422706
KN-62
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.
别名:
KN-62, 1-[N,O- bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II, 1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
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About This Item
推荐产品
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
protect from light
颜色
off-white
溶解性
methanol: 5 mg/mL
DMSO: soluble
运输
ambient
储存温度
2-8°C
InChI
1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3
InChI key
RJVLFQBBRSMWHX-UHFFFAOYSA-N
一般描述
A cell-permeable, reversible, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
生化/生理作用
Cell permeable: yes
Primary Target
cam kinase 2
cam kinase 2
Product does not compete with ATP.
Reversible: yes
Target Ki: 900 nM for rat brain CaM kinase II
警告
Toxicity: Standard Handling (A)
制备说明
Further dilute with aqueous buffer just prior to use.
重悬
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
其他说明
Minami, H., et al. 1994. Biochem. Biophys. Res. Commun.199, 241.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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