推荐产品
产品名称
KT5720, A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a.
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 1 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CNC7=O)cccc6)[C@H]5O[C@@]1([C@](C5)(O)C(=O)OCCCCCC)C
InChI
1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1
InChI key
ZHEHVZXPFVXKEY-RUAOOFDTSA-N
一般描述
一种有效、特异性、细胞渗透性、可逆性和ATP竞争性的蛋白激酶A（Ki=56 nM）抑制剂，通过化学修饰K-252a制备。不会显著影响PKC、PKG和MLCK的活性。抑制培养的神经元中的轴突分支。也可购买2 mM（50 µg/47 µl）KT 5720（目录号420323)）在DMSO中的溶液。
通过K-252a的化学修饰制备。一种有效、特异性、细胞可渗透性、可逆和ATP竞争性的蛋白激酶A（Ki=56 nM）抑制剂。不会显著影响PKC、PKG或MLCK的活性。抑制培养的神经元中的轴突分支。
生化/生理作用
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标Ki：56 nM，对于蛋白激酶A
首要靶标
PKA
PKA
警告
毒性：标准处理（A）
制备说明
仅在使用前再用水相缓冲液进行稀释。
重悬
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
其他说明
Simpson, C.S., and Morris, B.J.1995.Neuroscience 68, 97.
Cabell, L., and Audesirk, G. 1993.Int. J. Dev.Neurosci.11, 357.
Gadbois, D.M., et al. 1992.Proc.Natl.Acad.Sci. USA89, 8626.
Kase, H., et al. 1987.Biochem.Biophys.Res. Commun.142, 436.
Cabell, L., and Audesirk, G. 1993.Int. J. Dev.Neurosci.11, 357.
Gadbois, D.M., et al. 1992.Proc.Natl.Acad.Sci. USA89, 8626.
Kase, H., et al. 1987.Biochem.Biophys.Res. Commun.142, 436.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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