420139
JAK2 Inhibitor IV
The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
JAK2 Inhibitor IV, 3-Amino-5-(N- tert-butylsulfonamido-4-phenyl)-indazole
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所有图片(1)
About This Item
推荐产品
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
pale yellow
溶解性
ethanol: 3 mg/mL
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(NC(C)(C)C)c1ccc(cc1)c2cc3c([nH]nc3N)cc2
InChI
1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20)
InChI key
KFJCXIOVAGJCKB-UHFFFAOYSA-N
一般描述
An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett.19, 279.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Yong Yu et al.
Neural regeneration research, 18(5), 1132-1138 (2022-10-19)
Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization. P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) is a type of small non-coding RNA implicated in a variety
Md Al Nayem Chowdhury et al.
Cell death & disease, 13(7), 619-619 (2022-07-20)
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase
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