JNK Inhibitor II

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀ = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.

Cell permeable: yes

Primary Target
JNK 1, JNK 2, JNK 3

Product competes with ATP.

Reversible: yes

Target IC₅₀: 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3

Packaged under inert gas

Toxicity: Irritant (B)

A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.

Following initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.

Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA98, 13681.
Han, Z., et al. 2001. J. Clin. Invest.108, 73.

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