所有图片(1)
别名:
InSolution JAK抑制剂I, 2-（1，1-二甲基乙基）-9-氟-3，6-二氢-7H-苯并[h]-咪唑[4，5-f]异喹啉-7-酮，P6，吡啶酮6，DBI，JAK1抑制剂I，JAK2抑制剂I，JAK3抑制剂X
经验公式（希尔记法）:
C18H16FN3O
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
运输
wet ice
储存温度
2-8°C
InChI
1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChI key
VNDWQCSOSCCWIP-UHFFFAOYSA-N
一般描述
Janus蛋白酪氨酸激酶（JAKs）的有效抑制剂。显示对JAK1（对于鼠JAK1，IC50=15 nM）、JAK2（IC50=1 nM）、JAK3（Ki=5 nM）和Tyk2（IC50=1 nM）的有效抑制活性。它仅在高得多的浓度下抑制其他激酶。还抑制CTLL细胞的IL-2和IL-4依赖性增殖，并阻断STAT5的磷酸化。
生化/生理作用
5 nM，针对JAK3
主要靶标
鼠JAK1
鼠JAK1
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：分别针对鼠JAK1和JAK2的15 nM，1 nM；针对Tyk2为1 nM
包装
用惰性气体包装
警告
毒性：刺激性（B）
外形
10 mM（500 µg/162 µl）JAK抑制剂I（目录号420099）的DMSO溶液。
重悬
初次使用后，等分并冷藏（4°C）。
其他说明
Thompson, J.E., et al. 2002.Bioorg.Med. Chem. Lett.12, 1219.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
(Dimethylsulfoxide)
闪点(°C)
(Dimethylsulfoxide)
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