412510
IRE1抑制剂I,STF-083010
The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
IRE1抑制剂I,STF-083010, N-[(2-羟基萘-1-基)亚甲基]噻吩-2-磺酰胺,N-[(2-羟基-1-萘基)亚甲基]-2-噻吩磺酰胺,ER-核信号1抑制剂I,ERN1抑制剂I,肌醇调节蛋白1抑制剂I,STF083010
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所有图片(2)
About This Item
推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 100 mg/mL, clear, yellow
运输
ambient
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(\N=C\c2c3c(ccc2O)cccc3)c1[s]ccc1
InChI
1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChI key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
一般描述
一种细胞可渗透的水杨基化合物,可直接靶向Ireα1并破坏Ire1-XBP1(X-box结合蛋白),从而在RPMI8226多发性骨髓瘤(MM)细胞中未折叠蛋白反应(UPR)途径。选择性抑制Ire1的ER应激引发的核酸内切酶活性,并在转基因XBP1-luc小鼠(硼替佐米1mg/kg和60 mg/kg STF-083010,i.p.)中以60 µM和XBP1活性阻断MM细胞中XPB1 mRNA的剪接。与B、T和NK细胞相比,对CD138+细胞表现出优先的细胞毒性和抗肿瘤特性。
包装
用惰性气体包装
警告
毒性:监管审查(Z)
重悬
溶液中不稳定;仅在使用前进行复溶。
其他说明
Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010.Blood117, )1311.
Papandreou, I., et al. 2010.Blood117, )1311.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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eLife, 11 (2022-05-11)
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous
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The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce toxicity in retinal cells remain poorly understood. Here, we integrate
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Frontiers in neuroscience, 16, 906651-906651 (2022-07-06)
Astrocytes are one of the most numerous glial cells in the central nervous system (CNS) and provide essential support to neurons to ensure CNS health and function. During a neuropathological challenge, such as during human immunodeficiency virus (HIV)-1 infection or
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