412510
IRE1抑制剂I，STF-083010
The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
IRE1抑制剂I，STF-083010, N-[（2-羟基萘-1-基）亚甲基]噻吩-2-磺酰胺，N-[（2-羟基-1-萘基）亚甲基]-2-噻吩磺酰胺，ER-核信号1抑制剂I，ERN1抑制剂I，肌醇调节蛋白1抑制剂I，STF083010
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About This Item
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![PERK抑制剂I，GSK2606414 GSK2606414 is a cell-permeable, highly potent inhibitor of EIF2AK3/PERK (IC₅₀ = 0.4 nM; [ATP] = 5 µM). Targets PERK in its inactive DFG conformation at the ATP-binding region.](/deepweb/assets/sigmaaldrich/product/structures/180/559/efa716dc-d5fe-4339-a6f0-0103084fc04a/640/efa716dc-d5fe-4339-a6f0-0103084fc04a.png)
质量水平
方案
≥98% (HPLC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 100 mg/mL, clear, yellow
运输
ambient
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(\N=C\c2c3c(ccc2O)cccc3)c1[s]ccc1
InChI
1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChI key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
一般描述
一种细胞可渗透的水杨基化合物，可直接靶向Ireα1并破坏Ire1-XBP1（X-box结合蛋白），从而在RPMI8226多发性骨髓瘤（MM）细胞中未折叠蛋白反应（UPR）途径。选择性抑制Ire1的ER应激引发的核酸内切酶活性，并在转基因XBP1-luc小鼠（硼替佐米1mg/kg和60 mg/kg STF-083010，i.p.）中以60 µM和XBP1活性阻断MM细胞中XPB1 mRNA的剪接。与B、T和NK细胞相比，对CD138+细胞表现出优先的细胞毒性和抗肿瘤特性。
包装
用惰性气体包装
警告
毒性：监管审查（Z）
重悬
溶液中不稳定；仅在使用前进行复溶。
其他说明
Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010.Blood117, )1311.
Papandreou, I., et al. 2010.Blood117, )1311.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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