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Merck
CN
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文件

412510

Sigma-Aldrich

IRE1抑制剂I，STF-083010

The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.

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别名:
IRE1抑制剂I，STF-083010, N-[（2-羟基萘-1-基）亚甲基]噻吩-2-磺酰胺，N-[（2-羟基-1-萘基）亚甲基]-2-噻吩磺酰胺，ER-核信号1抑制剂I，ERN1抑制剂I，肌醇调节蛋白1抑制剂I，STF083010
经验公式（希尔记法）:
C15H11NO3S2
分子量:
317.38
MDL编号:
MFCD02332975
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

yellow

溶解性

DMSO: 100 mg/mL, clear, yellow

运输

ambient

储存温度

2-8°C

一般描述

一种细胞可渗透的水杨基化合物，可直接靶向Ireα1并破坏Ire1-XBP1（X-box结合蛋白），从而在RPMI8226多发性骨髓瘤（MM）细胞中未折叠蛋白反应（UPR）途径。选择性抑制Ire1的ER应激引发的核酸内切酶活性，并在转基因XBP1-luc小鼠（硼替佐米1mg/kg和60 mg/kg STF-083010，i.p.）中以60 µM和XBP1活性阻断MM细胞中XPB1 mRNA的剪接。与B、T和NK细胞相比，对CD138+细胞表现出优先的细胞毒性和抗肿瘤特性。

包装

用惰性气体包装

警告

毒性：监管审查（Z）

重悬

溶液中不稳定；仅在使用前进行复溶。

其他说明

Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010.Blood117, )1311.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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