product name
3-异丁基-1-甲基黄嘌呤, A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
ethanol: 10 mg/mL
DMSO: 100 mM
methanol: 50 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChI key
APIXJSLKIYYUKG-UHFFFAOYSA-N
一般描述
cAMP和cGMP磷酸二酯酶的一种非特异性细胞可渗透抑制剂（IC50 = 2-50 µM）。还可作为一种腺苷受体拮抗剂。已报道可抑制TNFα在脂肪细胞前体细胞中的表达。
cAMP和cGMP磷酸二酯酶的细胞可渗透非特异性抑制剂（IC50 = 2-50 µM）。还可作为一种腺苷受体拮抗剂。已报道可抑制TNF-α在脂肪细胞前体细胞中的表达。
生化/生理作用
主要靶标
cAMP和cGMP磷酸二酯酶
cAMP和cGMP磷酸二酯酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：2-50 µM，靶向cAMP和cGMP磷酸二酯酶
警告
毒性：标准处理（A）
制备说明
可能需要加热才能完全溶解。
重悬
在乙醇或甲醇中重溶后，冷藏保存（4°C）。在DMSO中重溶后，等分并冷冻保存（-20°C）。乙醇/甲醇和DMSO储备溶液可分别在4°C或-20°C下稳定保存长达6个月。
其他说明
Hube, F., et al. 1999.Horm.代谢Res.31, 359.
Morgan, A.J., et al. 1993.生物化学。Pharmacol.45, 2373.
Scamps, F., et al. 1993.Eur. J. Pharmacol.244, 119.
Turner, N.C., et al. 1993.Br. J. Pharmacol.108, 876.
Tamura, T., et al. 1991.J. Gen.Physiol.98, 95.
Beavo, J.A., and Reifsnyder, D.H.1990.Trends Pharmacol.Sci.11, 150.
Russell, T.R.1979.Proc.Natl.Acad.Sci. USA76, 4451.
Morgan, A.J., et al. 1993.生物化学。Pharmacol.45, 2373.
Scamps, F., et al. 1993.Eur. J. Pharmacol.244, 119.
Turner, N.C., et al. 1993.Br. J. Pharmacol.108, 876.
Tamura, T., et al. 1991.J. Gen.Physiol.98, 95.
Beavo, J.A., and Reifsnyder, D.H.1990.Trends Pharmacol.Sci.11, 150.
Russell, T.R.1979.Proc.Natl.Acad.Sci. USA76, 4451.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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