407951
离子霉素，游离酸，聚集链霉菌溶液
别名:
离子霉素，游离酸，来源于溶液中的Streptomyces conglobatus
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关于此项目
经验公式（希尔记法）:
C41H72O9
化学文摘社编号:
分子量:
709.00
NACRES:
NA.76
UNSPSC Code:
12352106
MDL number:
InChI
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1
InChI key
PGHMRUGBZOYCAA-OJFQOPKISA-N
assay
≥90% (HPLC)
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
clear colorless to slight yellow
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
首要靶标
Ca2+的移动离子载体
Ca2+的移动离子载体
Disclaimer
毒性：刺激性（B）
General description
对二价阳离子具有高度特异性（Ca2+ > Mg2+ >> Sr2+ = Ba2+）。比抗生素A23187作为Ca2+的移动离子载体更有效。在pH 7和9.5之间与Ca2+的络合，在紫外线范围内产生了显著的吸光值；然而，相比于A23817（货号100105），它是非荧光的。可用于研究Ca2+跨生物膜的运输以及细胞质游离Ca2+的测量。在胚胎皮质神经元中诱导凋亡神经元退化。还可在成熟的伯基特淋巴瘤细胞系的G1间隔期诱导细胞周期阻滞。
Other Notes
Aagaard-Tillery, K.M., and Jelinek, D.F.1995.J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
Packaging
用惰性气体包装
Physical form
一种5 mM（1 mg/282 µl）的碘霉素、游离酸、链霉菌溶液（货号407950），溶剂为DMSO
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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Cellular and molecular gastroenterology and hepatology, 12(2), 395-425 (2021-03-07)
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