检测方案
≥90% (HPLC)
质量水平
形式
solution
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
clear colorless to slight yellow
运输
wet ice
储存温度
−20°C
InChI
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1
InChI key
PGHMRUGBZOYCAA-OJFQOPKISA-N
一般描述
对二价阳离子具有高度特异性（Ca2+ > Mg2+ >> Sr2+ = Ba2+）。比抗生素A23187作为Ca2+的移动离子载体更有效。在pH 7和9.5之间与Ca2+的络合，在紫外线范围内产生了显著的吸光值；然而，相比于A23817（货号100105），它是非荧光的。可用于研究Ca2+跨生物膜的运输以及细胞质游离Ca2+的测量。在胚胎皮质神经元中诱导凋亡神经元退化。还可在成熟的伯基特淋巴瘤细胞系的G1间隔期诱导细胞周期阻滞。
生化/生理作用
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
首要靶标
Ca2+的移动离子载体
Ca2+的移动离子载体
包装
用惰性气体包装
警告
毒性：刺激性（B）
外形
一种5 mM（1 mg/282 µl）的碘霉素、游离酸、链霉菌溶液（货号407950），溶剂为DMSO
重悬
初次融化后，等分并冷冻（-20°C）。
其他说明
Aagaard-Tillery, K.M., and Jelinek, D.F.1995.J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
Beibei Wu et al.
Cell reports, 36(8), 109603-109603 (2021-08-26)
Sustained activation of the Ca2+-release-activated Ca2+ (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability remain poorly understood. We find that plasma membrane localization of ORAI1, the pore subunit of CRAC channels, is limited in effector
Fang-Yuan Mao et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 395-425 (2021-03-07)
Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. Rev-erbα was examined in gastric samples from H pylori-infected patients and mice. Gastric epithelial cells (GECs)
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